Bone Tissue Quality Determination of Mice Through a Novel Reference Point Indentation Technique

Reference point indentation is not indicative of whole mouse bone measures of stress intensity fracture toughness

Bone fragility is a concern for aged and diseased bone. Measuring bone toughness and understanding fracture properties of the bone are critical for predicting fracture risk associated with age and disease and for preclinical testing of therapies. A reference point indentation technique (BioDent) has recently been developed to determine bone's resistance to fracture in a minimally invasive way b...

Bone Tissue Properties Measurement by Reference Point Indentation in Glucocorticoid-Induced Osteoporosis.

Glucocorticoids, widely used in inflammatory disorders, rapidly increase bone fragility and, therefore, fracture risk. However, common bone densitometry measurements are not sensitive enough to detect these changes. Moreover, densitometry only partially recognizes treatment-induced fracture reductions in osteoporosis. Here, we tested whether the reference point indentation technique could detec...

Investigation of Ultrastructural and Mechanical Properties of Rat Cortical Bone Using Micro-ct, Three- Point Bending Testing, and the Reference Point Indentation Technique By

Variability of in vivo reference point indentation in skeletally mature inbred rats.

Reference point indentation (RPI) has emerged as a novel tool to measure material-level biomechanical properties in vivo. Human studies have been able to differentiate fracture versus non-fracture patients while a dog study has shown the technique can differentiate drug treatment effects. The goal of this study was to extend this technology to the in vivo measurement of rats, one of the most co...

A Novel Technique for Determination of the Onset of Alkane Induced Asphaltene Precipitation Using Accurate Density Measurements

Onset of asphaltene precipitation is the key parameter in dealing with asphaltene problems because it is the starting point of the asphaltene separation from the solution. In this study, a new technique is provided based on the experimental observations for the determination of the onset of asphaltene precipitation using accurate density measurements of the crude oils upon titration with precip...